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test video post – neural interfacing

test video post – neural interfacing



The recent explosion in development of micro/nanotechnologies is increasingly providing opportunities to use devices to investigate and/or aid neurological functionality. Neural interfaces link the nervous system to internal or external devices – creating possibilities for bi-directional information exchange, (and its correction), between different areas of the nervous system (normally through a device) – thereby recording, stimulating, restoring or supplementing neurological functionality. For example, Brain Computer Interfacing (BCI) is a promising technology that can potentially help return lost motor and sensory function to individuals suffering from debilitating injuries to the nervous system.

A key component of BCIs are intracortical neural interfaces (INIs), which can provide the quality of neural signals required to control an external prosthesis such as a robotic arm. In reality, however, the robust foreign body response and blood-brain barrier breach caused by indwelling neural interfaces causes degradation of signal quality, and chronic device failure: material and structural incompatible with brain tissue, make INIs incapable of functioning chronically. Our work in this field aims at designing neurointegrative intracortical neural interfacing systems, and to develop non-invasive implantation strategies, to help reduce the foreign body response to the indwelling INIs and consequential chronic failure.

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video test with youtube link

The recent explosion in development of micro/nanotechnologies is increasingly providing opportunities to use devices to investigate and/or aid neurological functionality. Neural interfaces link the nervous system to internal or external devices – creating possibilities for bi-directional information exchange, (and its correction), between different areas of the nervous system (normally through a device) – thereby recording, stimulating, restoring or supplementing neurological functionality. For example, Brain Computer Interfacing (BCI) is a promising technology that can potentially help return lost motor and sensory function to individuals suffering from debilitating injuries to the nervous system.

A key component of BCIs are intracortical neural interfaces (INIs), which can provide the quality of neural signals required to control an external prosthesis such as a robotic arm. In reality, however, the robust foreign body response and blood-brain barrier breach caused by indwelling neural interfaces causes degradation of signal quality, and chronic device failure: material and structural incompatible with brain tissue, make INIs incapable of functioning chronically. Our work in this field aims at designing neurointegrative intracortical neural interfacing systems, and to develop non-invasive implantation strategies, to help reduce the foreign body response to the indwelling INIs and consequential chronic failure.

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Research

Research

Carbohydrates are an important and often underappreciated class of biological macromolecules that play important roles in development, and in repair and regeneration post-injury. Defects in carbohydrate biosynthesis and alterations in carbohydrate composition are known to result in severe developmental defects, cartilage breakdown and reduced myocardial tissue integrity. Sugars also play important roles in a number of biological processes, a few of which include: binding trophic factors and cytokines, controlling stem cell differentiation, cell fate and self-renewal, directing neuronal path-finding, and protecting and stabilizing proteins. While bio-compatible synthetic polymer and peptide based biomaterials have gained widespread acceptance for regenerative medicine applications, the potential of sugar based biomaterials has not been fully explored. My research integrates methodologies from engineering disciplines and biology, to: a) Gain a fundamental understanding of the role of carbohydrates associated with “scar tissue” surrounding injuries to the nervous system; and b) Devise strategies to rationally design “glycoengineered” therapeutic interventions that can ultimately be tested in clinically relevant models.

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