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Translational Glycomaterials and Neural Repair Lab
Regenerative Bioscience Center, University of Georgia
Translational Glycomaterials and Neural Repair Lab
University of Georgia, Regenerative Bioscience Center
Injuries and diseases of the central nervous system have limited treatment options, resulting in devastating long-term consequences for individuals who suffer from them. Research in the Translational Glycomaterials and Neural Repair Lab is focused on investigating brain extracellular matrix adaptations in injury and disease and devising novel and clinically translatable strategies to promote endogenous repair and prevent disease progression.
CMaT
Research
#1 Glycomaterials Design and Development
#2 Traumatic Brain Injuries (TBI)
#3 Brain Tumors
#4 Alzheimer’s Disease and Related Dementias
An open-source Automatized Reach and Grasp (AutoRG) Testing Arena for rodent forelimb motor function assessment
Development of a label-free impedance sensing assay to predict the tumor targeting potency of therapeutic CAR T cells
GBM
Glioblastoma (GBM) is the most commonly occurring brain tumor in adults. It carries a devastating prognosis, with the majority of patients rarely surviving beyond 12-15 months post-diagnosis and treatment. There are no effective treatments and the current standard of care has not changed over the past two decades. We are interested in understanding mechanisms by which brain tumors adapt and alter their microenvironment in order to spread and evade therapeutic targeting. In doing so, we hope to uncover novel therapeutic targets and develop more effective treatments to improve patient survival.
TBI
Over 2.5 million people sustain traumatic brain injuries (TBIs) every year. These can span a wide range of severities from mild, moderate, to severe injuries. Individuals who sustain a TBI experience lifelong disabilities and are at a high risk of developing Alzheimer’s Disease (AD) and AD related dementias (ADRD). There are currently no effective treatments for TBI. We are developing novel therapeutic strategies that are aimed at protecting brain tissue and accelerating endogenous repair and refunctionalization of brain circuitry after TBI. These approaches address the urgent and unmet clinical need for effective therapeutics across all TBI severities.
